› 6u69

X-ray diffraction
2.61Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-103404 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
non-specific serine/threonine protein kinase Chain: A
Molecule details ›
Chain: A
Length: 309 amino acids
Theoretical weight: 35.4 KDa
Source organism: Candida albicans SC5314
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0A1D8PKB4 (Residues: 37-345; Coverage: 62%)
Gene names: CAALFM_C305650WA, YCK2, orf19.7001
Sequence domains: Protein kinase domain

Ligands and Environments

3 bound ligands:
Ligand SO4 1 x SO4
Ligand GOL 1 x GOL
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: R3
Unit cell:
a: 91.771Å b: 91.771Å c: 119.83Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.194 0.191 0.246
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

11 review citations

Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond.
Lee et al. (2021)
10 more

1 mention without citation

Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2.
Caplan et al. (2020)