› 6txq

X-ray diffraction
1.73Å resolution

The high resolution structure of the FERM domain and helical linker of human moesin

Released:
DOI: 10.2210/pdb6txq/pdb
PDB entry 6txq coloured by chain, front view.
PDB entry 6txq coloured by chain, side view.
PDB entry 6txq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
Du Y, Bradshaw WJ, Leisner TM, Annor-Gyamfi JK, Qian K, Bashore FM, Sikdar A, Nwogbo FO, Ivanov AA, Frye SV, Gileadi O, Brennan PE, Levey AI, Axtman AD, Pearce KH, Fu H, Katis VL
J Biol Chem 105382 (2023)
PMID: 37866628

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150637 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Moesin Chain: AAA
Molecule details ›
Chain: AAA
Length: 347 amino acids
Theoretical weight: 41.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P26038 (Residues: 1-346; Coverage: 60%)
Gene name: MSN
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P43212
Unit cell:
a: 112.419Å b: 112.419Å c: 61.13Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.2 0.233
Expression system: Escherichia coli BL21(DE3)

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Citations

1 review citation

Fused Tetrahydroquinolines Are Interfering with Your Assay.
Bashore et al. (2023)