› 6tvm

Solution NMR

LEDGF/p75 dimer (residues 345-467)

Released:
DOI: 10.2210/pdb6tvm/pdb
PDB entry 6tvm coloured by chain, ensemble of 30 models, front view.
PDB entry 6tvm coloured by chain, ensemble of 30 models, side view.
PDB entry 6tvm coloured by chain, ensemble of 30 models, top view.
Source organism: Homo sapiens
Primary publication:
Molecular Mechanism of LEDGF/p75 Dimerization.
Lux V, Brouns T, Čermáková K, Srb P, Fábry M, Mádlíková M, Hořejší M, Kukačka Z, Novák P, Kugler M, Brynda J, DeRijck J, Christ F, Debyser Z, Veverka V
Structure 28 1288-1299.e7 (2020)
PMID: 32946742

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130990 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PC4 and SFRS1-interacting protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 128 amino acids
Theoretical weight: 14.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75475 (Residues: 345-467; Coverage: 23%)
Gene names: DFS70, LEDGF, PSIP1, PSIP2
Sequence domains: Lens epithelium-derived growth factor (LEDGF)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 45%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

1 review citation

The TFIIS N-terminal domain (TND): a transcription assembly module at the interface of order and disorder.
Cermakova et al. (2023)
1 other article