Electron Microscopy
2.5Å resolution

PKM2 in complex with Compound 6

Source organism: Homo sapiens
Primary publication:
Fragment-based drug discovery using cryo-EMs.
Drug Discov. Today (2019)
PMID: 31877353
Related structures: EMD-10577

Function and Biology Details

Reaction catalysed:
ATP + pyruvate = ADP + phosphoenolpyruvate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Pyruvate kinase PKM Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 548 amino acids
Theoretical weight: 59.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P14618 (Residues: 2-531; Coverage: 100%)
  • Best match: P14618-3 (Residues: 68-516)
Gene names: OIP3, PK2, PK3, PKM, PKM2
Sequence domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.5Å
Relevant EMDB volumes: EMD-10577
Expression system: Escherichia coli