› 6tt5

X-ray diffraction
1.5Å resolution

Crystal structure of DCLRE1C/Artemis

Released:
DOI: 10.2210/pdb6tt5/pdb
PDB entry 6tt5 coloured by chain, front view.
PDB entry 6tt5 coloured by chain, side view.
PDB entry 6tt5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.
Yosaatmadja Y, Baddock HT, Newman JA, Bielinski M, Gavard AE, Mukhopadhyay SMM, Dannerfjord AA, Schofield CJ, McHugh PJ, Gileadi O
Nucleic Acids Res 49 9310-9326 (2021)
PMID: 34387696

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188752 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein artemis Chain: AAA
Molecule details ›
Chain: AAA
Length: 362 amino acids
Theoretical weight: 41.77 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q96SD1 (Residues: 1-361; Coverage: 52%)
Gene names: ARTEMIS, ASCID, DCLRE1C, SCIDA, SNM1C
Sequence domains: DNA repair metallo-beta-lactamase

Ligands and Environments

3 bound ligands:
Ligand EDO 6 x EDO
Ligand ZN 2 x ZN
Ligand NI 1 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P1
Unit cell:
a: 35.871Å b: 47.993Å c: 48.246Å
α: 82.607° β: 76.37° γ: 85.983°
R-values:
R R work R free
0.167 0.166 0.192
Expression system: Spodoptera frugiperda

Quick links

Citations

4 review citations

V(D)J Recombination: Recent Insights in Formation of the Recombinase Complex and Recruitment of DNA Repair Machinery.
Christie et al. (2022)
3 more

7 mentions without citation

The SNM1A DNA repair nuclease.
Baddock et al. (2020)
6 more