› 6tt2

X-ray diffraction
1.36Å resolution

The PH domain of Bruton's tyrosine kinase mutant R28C

Released:
DOI: 10.2210/pdb6tt2/pdb
PDB entry 6tt2 coloured by chain, front view.
PDB entry 6tt2 coloured by chain, side view.
PDB entry 6tt2 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Brear P, Wagstaff J, Hyvonen M

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170299 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase BTK Chains: A, B
Molecule details ›
Chains: A, B
Length: 169 amino acids
Theoretical weight: 19.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q06187 (Residues: 2-170; Coverage: 26%)
Gene names: AGMX1, ATK, BPK, BTK
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand MG 2 x MG
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P21
Unit cell:
a: 49.247Å b: 60.374Å c: 56.394Å
α: 90° β: 98.12° γ: 90°
R-values:
R R work R free
0.205 0.203 0.234
Expression system: Escherichia coli BL21(DE3)

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