› 6ts0

X-ray diffraction
2.2Å resolution

Crystal structure of human L ferritin (HuLf) triple variant E60A-E61A-E64A Fe(III)-loaded for 30 minutes

Released:
DOI: 10.2210/pdb6ts0/pdb
PDB entry 6ts0 coloured by chain, front view.
PDB entry 6ts0 coloured by chain, side view.
PDB entry 6ts0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Iron Biomineral Growth from the Initial Nucleation Seed in L-Ferritin.
Ciambellotti S, Pozzi C, Mangani S, Turano P
Chemistry 26 5770-5773 (2020)
PMID: 32027764

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136239 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ferritin light chain Chain: AAA
Molecule details ›
Chain: AAA
Length: 175 amino acids
Theoretical weight: 19.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P02792 (Residues: 1-175; Coverage: 100%)
Gene name: FTL
Sequence domains: Ferritin-like domain

Ligands and Environments

3 bound ligands:
Ligand FE 9 x FE
Ligand O 1 x O
Ligand CD 1 x CD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: I432
Unit cell:
a: 151.386Å b: 151.386Å c: 151.386Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.204 0.248
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Advances in Ferritin Physiology and Possible Implications in Bacterial Infection.
Gehrer et al. (2023)
5 other articles