6tpk

X-ray diffraction
3.2Å resolution

Crystal structure of the human oxytocin receptor

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human oxytocin receptor.
Sci Adv 6 eabb5419 (2020)
PMID: 32832646

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Oxytocin receptor Chain: A
Molecule details ›
Chain: A
Length: 502 amino acids
Theoretical weight: 56.16 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P30559 (Residues: 35-356; Coverage: 83%)
Gene name: OXTR
Sequence domains: 7 transmembrane receptor (rhodopsin family)

Ligands and Environments

3 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2221
Unit cell:
a: 76.987Å b: 78.858Å c: 283.486Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.252 0.252 0.266
Expression system: Spodoptera frugiperda