6td3

X-ray diffraction
3.46Å resolution

Function and Biology Details

Reactions catalysed:
ATP + a protein = ADP + a phosphoprotein
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
DNA damage-binding protein 1 Chains: A, D, G
Molecule details ›
Chains: A, D, G
Length: 840 amino acids
Theoretical weight: 93.68 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q16531 (Residues: 1-395, 708-1140; Coverage: 73%)
  • Best match: Q16531-2 (Residues: 59-451)
Gene names: DDB1, XAP1
Sequence domains:
Cyclin-dependent kinase 12 Chains: B, E, H
Molecule details ›
Chains: B, E, H
Length: 344 amino acids
Theoretical weight: 40.14 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9NYV4 (Residues: 712-1051; Coverage: 23%)
Gene names: CDK12, CRK7, CRKRS, KIAA0904
Sequence domains: Protein kinase domain
Cyclin-K Chains: C, F, I
Molecule details ›
Chains: C, F, I
Length: 271 amino acids
Theoretical weight: 31.7 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O75909 (Residues: 1-267; Coverage: 46%)
Gene names: CCNK, CPR4
Sequence domains: Cyclin, N-terminal domain

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P3121
Unit cell:
a: 250.749Å b: 250.749Å c: 217.92Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.195 0.194 0.22
Expression system: Trichoplusia ni