X-ray diffraction
1.51Å resolution

Crystal structure of AmpC from E.coli with Avibactam


Function and Biology Details

Reaction catalysed:
A beta-lactam + H(2)O = a substituted beta-amino acid
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Beta-lactamase Chain: A
Molecule details ›
Chain: A
Length: 358 amino acids
Theoretical weight: 39.59 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli str. K-12 substr. W3110
  • Canonical: P00811 (Residues: 20-377; Coverage: 100%)
Gene names: JW4111, ampA, ampC, b4150
Sequence domains: Beta-lactamase

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P4332
Unit cell:
a: 138.083Å b: 138.083Å c: 138.083Å
α: 90° β: 90° γ: 90°
R R work R free
0.159 0.158 0.181
Expression system: Escherichia coli str. K-12 substr. W3110