› 6t28

X-ray diffraction
1.55Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184844 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium/calmodulin-dependent protein kinase type 1D Chain: AAA
Molecule details ›
Chain: AAA
Length: 385 amino acids
Theoretical weight: 42.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IU85 (Residues: 1-385; Coverage: 100%)
Gene names: CAMK1D, CAMKID
Sequence domains: Protein kinase domain

Ligands and Environments

3 bound ligands:
Ligand SO4 3 x SO4
Ligand EDO 3 x EDO
Ligand M92 1 x M92
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Unit cell:
a: 57.64Å b: 45.62Å c: 108.949Å
α: 90° β: 104.439° γ: 90°
R-values:
R R work R free
0.159 0.157 0.183
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Genetic Variants in Transcription Factor Binding Sites in Humans: Triggered by Natural Selection and Triggers of Diseases.
Tseng et al. (2021)
6 other articles

1 mention without citation

Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model.
Fromont et al. (2020)