› 6t1v

X-ray diffraction
2.21Å resolution

Structure of PPARg H494Y mutant in complex with GW1929

Released:
DOI: 10.2210/pdb6t1v/pdb
PDB entry 6t1v coloured by chain, front view.
PDB entry 6t1v coloured by chain, side view.
PDB entry 6t1v coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Rochel N

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153377 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peroxisome proliferator-activated receptor gamma Chain: A
Molecule details ›
Chain: A
Length: 279 amino acids
Theoretical weight: 31.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37231 (Residues: 231-505; Coverage: 55%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Chain: C
Molecule details ›
Chain: C
Length: 14 amino acids
Theoretical weight: 1.52 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9UBK2 (Residues: 139-152; Coverage: 2%)
Gene names: LEM6, PGC1, PGC1A, PPARGC1, PPARGC1A

Ligands and Environments

1 bound ligand:
Ligand EDK 1 x EDK
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: I222
Unit cell:
a: 56.349Å b: 120.741Å c: 149.843Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.166 0.196
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

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