› 6t1l

X-ray diffraction
2Å resolution

Crystal structure of MLLT1 (ENL) YEATS domain in complexed with piperazine-urea derivative 3

Released:
DOI: 10.2210/pdb6t1l/pdb
PDB entry 6t1l coloured by chain, front view.
PDB entry 6t1l coloured by chain, side view.
PDB entry 6t1l coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1.
Ni X, Heidenreich D, Christott T, Bennett J, Moustakim M, Brennan PE, Fedorov O, Knapp S, Chaikuad A
ACS Med Chem Lett 10 1661-1666 (2019)
PMID: 31857843

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169829 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein ENL Chain: A
Molecule details ›
Chain: A
Length: 154 amino acids
Theoretical weight: 18.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q03111 (Residues: 1-148; Coverage: 27%)
Gene names: ENL, LTG19, MLLT1, YEATS1
Sequence domains: YEATS family

Ligands and Environments

2 bound ligands:
Ligand EDO 10 x EDO
Ligand M7N 1 x M7N
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P43212
Unit cell:
a: 49.078Å b: 49.078Å c: 131.708Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.218 0.265
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Structure, function and inhibition of critical protein-protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins.
Li et al. (2021)
1 more

2 mentions without citation

Urea-aromatic interactions in biology.
Raghunathan et al. (2020)
1 more