› 6sx8

X-ray diffraction
1.8Å resolution

Mopeia Virus Exonuclease domain complexed with Manganese

Released:
DOI: 10.2210/pdb6sx8/pdb
PDB entry 6sx8 coloured by chain, front view.
PDB entry 6sx8 coloured by chain, side view.
PDB entry 6sx8 coloured by chain, top view.
Source organism: Mopeia virus AN20410
Primary publication:
Inhibition of Arenaviridae nucleoprotein exonuclease by bisphosphonate
Nguyen THV, Yekwa E, Selisko B, Canard B, Alvarez K, Ferron F
IUCrJ (2022)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177802 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoprotein Chains: A, B
Molecule details ›
Chains: A, B
Length: 206 amino acids
Theoretical weight: 23.56 KDa
Source organism: Mopeia virus AN20410
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5S581 (Residues: 365-570; Coverage: 36%)
Gene names: N, NP
Sequence domains: Arenavirus nucleocapsid C-terminal domain

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand MN 2 x MN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P2
Unit cell:
a: 45.537Å b: 38.014Å c: 137.23Å
α: 90° β: 92.94° γ: 90°
R-values:
R R work R free
0.213 0.211 0.254
Expression system: Escherichia coli

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