6spk

X-ray diffraction
2.77Å resolution

A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 6

Released:
Source organism: Homo sapiens
Entry authors: Chantadul V, Amporndanai K, Wright G, Shahid M, Antonyuk S, Hasnain S

Function and Biology Details

Reaction catalysed:
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Superoxide dismutase [Cu-Zn] Chains: A, B, E, F, I, J
Molecule details ›
Chains: A, B, E, F, I, J
Length: 153 amino acids
Theoretical weight: 15.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00441 (Residues: 2-154; Coverage: 99%)
Gene name: SOD1
Sequence domains: Copper/zinc superoxide dismutase (SODC)

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2
Unit cell:
a: 112.663Å b: 195.546Å c: 76.34Å
α: 90° β: 98.08° γ: 90°
R-values:
R R work R free
0.213 0.211 0.229
Expression system: Escherichia coli