› 6slg

X-ray diffraction
1.33Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151235 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mitogen-activated protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 381 amino acids
Theoretical weight: 43.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P28482 (Residues: 1-360; Coverage: 100%)
Gene names: ERK2, MAPK1, PRKM1, PRKM2
Sequence domains: Protein kinase domain
ERK-tide Chain: B
Molecule details ›
Chain: B
Length: 5 amino acids
Theoretical weight: 492 Da
Source organism: Homo sapiens
Expression system: Escherichia coli

Ligands and Environments

3 bound ligands:
Ligand LHZ 1 x LHZ
Ligand SO4 2 x SO4
Ligand EDO 4 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P21
Unit cell:
a: 48.72Å b: 70.51Å c: 60.42Å
α: 90° β: 109.91° γ: 90°
R-values:
R R work R free
0.207 0.206 0.228
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Emerging strategies to target RAS signaling in human cancer therapy.
Chen et al. (2021)
2 more

22 mentions without citation

Study on Medication Rules of Traditional Chinese Medicine against Antineoplastic Drug-Induced Cardiotoxicity Based on Network Pharmacology and Data Mining.
Dan et al. (2020)
21 more