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Structure of T. thermophilus AspRS in Complex with 5'-O-(N-(L-aspartyl)-sulfamoyl)adenosine

Source organism: Thermus thermophilus
Biochemical function: ligase activity
Biological process: aspartyl-tRNA aminoacylation
Cellular component: cytoplasm

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EC 6.1.1.12: Aspartate--tRNA ligase

Reaction catalysed:
ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)
Systematic name:
L-aspartate:tRNA(Asp) ligase (AMP-forming)
Alternative Name(s):
  • Aspartic acid translase
  • Aspartyl ribonucleate synthetase
  • Aspartyl ribonucleic synthetase
  • Aspartyl-tRNA synthetase
  • Aspartyl-transfer RNA synthetase
  • Aspartyl-transfer ribonucleic acid synthetase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02938
Domain description: GAD domain
Occurring in:
  1. Aspartate--tRNA(Asp) ligase
The deposited structure of PDB entry 6sjc contains 2 copies of Pfam domain PF02938 (GAD domain) in Aspartate--tRNA(Asp) ligase. Showing 1 copy in chain B.

PF00152
Domain description: tRNA synthetases class II (D, K and N)
Occurring in:
  1. Aspartate--tRNA(Asp) ligase
The deposited structure of PDB entry 6sjc contains 2 copies of Pfam domain PF00152 (tRNA synthetases class II (D, K and N) ) in Aspartate--tRNA(Asp) ligase. Showing 1 copy in chain B.

PF01336
Domain description: OB-fold nucleic acid binding domain
Occurring in:
  1. Aspartate--tRNA(Asp) ligase
The deposited structure of PDB entry 6sjc contains 2 copies of Pfam domain PF01336 (OB-fold nucleic acid binding domain) in Aspartate--tRNA(Asp) ligase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR002312
Domain description: Aspartyl/Asparaginyl-tRNA synthetase, class IIb
Occurring in:
  1. Aspartate--tRNA(Asp) ligase
IPR004115
Domain description: GAD-like domain superfamily
Occurring in:
  1. Aspartate--tRNA(Asp) ligase
IPR045864
Domain description: Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
Occurring in:
  1. Aspartate--tRNA(Asp) ligase
IPR012340
Domain description: Nucleic acid-binding, OB-fold
Occurring in:
  1. Aspartate--tRNA(Asp) ligase
IPR004524
Domain description: Aspartate-tRNA ligase, type 1
Occurring in:
  1. Aspartate--tRNA(Asp) ligase
IPR029351
Domain description: GAD domain
Occurring in:
  1. Aspartate--tRNA(Asp) ligase
IPR047090
Domain description: Aspartate-tRNA ligase, type 1, core domain
Occurring in:
  1. Aspartate--tRNA(Asp) ligase
IPR006195
Domain description: Aminoacyl-tRNA synthetase, class II
Occurring in:
  1. Aspartate--tRNA(Asp) ligase
IPR004364
Domain description: Aminoacyl-tRNA synthetase, class II (D/K/N)
Occurring in:
  1. Aspartate--tRNA(Asp) ligase
IPR004365
Domain description: OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
Occurring in:
  1. Aspartate--tRNA(Asp) ligase
IPR047089
Domain description: Aspartate-tRNA ligase, type 1, anticodon recognition domain
Occurring in:
  1. Aspartate--tRNA(Asp) ligase

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