› 6si5

X-ray diffraction
2.1Å resolution

T. cruzi FPPS in complex with 1-methyl-5-(4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-carbonyl)pyridin-2(1H)-one

Released:
DOI: 10.2210/pdb6si5/pdb
PDB 6si5 coloured by chain and viewed from the front.
PDB 6si5 coloured by chain and viewed from the side.
PDB 6si5 coloured by chain and viewed from the top.
Source organism: Trypanosoma cruzi
Entry authors: Petrick JK, Muenzker L, Schleberger C, Cornaciu I, Clavel D, Marquez JA, Jahnke W

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Farnesyl pyrophosphate synthase Chain: A
Molecule details ›
Chain: A
Length: 364 amino acids
Theoretical weight: 41.36 KDa
Source organism: Trypanosoma cruzi
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8WS26 (Residues: 64-425; Coverage: 85%)
Sequence domains: Polyprenyl synthetase

Ligands and Environments

2 bound ligands:
Ligand LEQ 1 x LEQ
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: P6122
Unit cell:
a: 58.061Å b: 58.061Å c: 396.793Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.203 0.2 0.26
Expression system: Escherichia coli BL21(DE3)

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