6sgx

Electron Microscopy
3.7Å resolution

Structure of protomer 1 of the ESX-3 core complex

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
ESX-3 secretion system ATPase EccB3 Chain: A
Molecule details ›
Chain: A
Length: 79 amino acids
Theoretical weight: 8.88 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
Expression system: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0QQ39 (Residues: 11-89; Coverage: 15%)
Gene names: MSMEG_0616, MSMEI_0600, eccB3
ESX-3 secretion system protein EccD3 Chains: B, C
Molecule details ›
Chains: B, C
Length: 465 amino acids
Theoretical weight: 47.11 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
Expression system: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0QQ46 (Residues: 8-472; Coverage: 98%)
Gene names: MSMEG_0623, MSMEI_0607, eccD3, snm
Sequence domains: WXG100 protein secretion system (Wss), protein YukD
ESX-3 secretion system protein EccC3 Chain: F
Molecule details ›
Chain: F
Length: 401 amino acids
Theoretical weight: 44.65 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
Expression system: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0QQ40 (Residues: 2-402; Coverage: 30%)
Gene names: MSMEG_0617, MSMEI_0601, eccC3
ESX-3 secretion system protein EccE3 Chain: G
Molecule details ›
Chain: G
Length: 285 amino acids
Theoretical weight: 30.81 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
Expression system: Mycolicibacterium smegmatis MC2 155
UniProt:
  • Canonical: A0QQ48 (Residues: 1-285; Coverage: 92%)
Gene names: MSMEG_0626, MSMEI_0609, eccE3
Sequence domains: Putative type VII ESX secretion system translocon, EccE

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.7Å
Relevant EMDB volumes: EMD-10187
Expression system: Mycolicibacterium smegmatis MC2 155