6s8u

X-ray diffraction
3.67Å resolution

Structure of the PfEMP1 IT4var13 DBLbeta domain bound to ICAM-1

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-122663 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Erythrocyte membrane protein 1 Chain: A
Molecule details ›
Chain: A
Length: 469 amino acids
Theoretical weight: 53.84 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
UniProt:
  • Canonical: E0A3B3 (Residues: 733-1201; Coverage: 15%)
Sequence domains: Duffy binding domain
Intercellular adhesion molecule 1 Chain: B
Molecule details ›
Chain: B
Length: 186 amino acids
Theoretical weight: 20.5 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P05362 (Residues: 28-212; Coverage: 37%)
Gene name: ICAM1
Sequence domains: Intercellular adhesion molecule (ICAM), N-terminal domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P6522
Unit cell:
a: 142.41Å b: 142.41Å c: 224.225Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.242 0.24 0.286
Expression systems:
  • Escherichia coli
  • Homo sapiens