X-ray diffraction
1.6Å resolution

LXRbeta ligand binding domain in complex with small molecule inhibitors


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Oxysterols receptor LXR-beta Chain: A
Molecule details ›
Chain: A
Length: 245 amino acids
Theoretical weight: 28.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P55055 (Residues: 216-460; Coverage: 53%)
Gene names: LXRB, NER, NR1H2, UNR
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P3221
Unit cell:
a: 58.728Å b: 58.728Å c: 148.026Å
α: 90° β: 90° γ: 120°
R R work R free
0.182 0.18 0.214
Expression system: Escherichia coli