› 6s4n

X-ray diffraction
1.9Å resolution

LXRbeta ligand binding domain in comlpex with small molecule inhibitors

Released:
DOI: 10.2210/pdb6s4n/pdb
PDB entry 6s4n coloured by chain, front view.
PDB entry 6s4n coloured by chain, side view.
PDB entry 6s4n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis identifies an escape route from the adverse lipogenic effects of liver X receptor ligands.
Belorusova AY, Evertsson E, Hovdal D, Sandmark J, Bratt E, Maxvall I, Schulman IG, Åkerblad P, Lindstedt EL
Commun Biol 2 431 (2019)
PMID: 31799433

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157159 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Oxysterols receptor LXR-beta Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 245 amino acids
Theoretical weight: 28.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P55055 (Residues: 216-460; Coverage: 53%)
Gene names: LXRB, NER, NR1H2, UNR
Sequence domains: Ligand-binding domain of nuclear hormone receptor

Ligands and Environments

2 bound ligands:
Ligand KUW 7 x KUW
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21
Unit cell:
a: 55.433Å b: 109.398Å c: 88.98Å
α: 90° β: 90.878° γ: 90°
R-values:
R R work R free
0.216 0.215 0.245
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Lipid metabolism in cancer progression and therapeutic strategies.
Fu et al. (2021)
4 more

2 mentions without citation

Virtual screening of potentially endocrine-disrupting chemicals against nuclear receptors and its application to identify PPARγ-bound fatty acids.
Jaladanki et al. (2021)
1 more