PDB 6s1f biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1 (preferred)

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Assembly Name: Receptor-interacting serine/threonine-protein kinase 2
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Multimeric state: homo dimer

Accessible surface area: 25977.93 Å²

Buried surface area: 3777.65 Å²

Dissociation area: 1,888.82 Å²

Dissociation energy (ΔG^diss): 23.74 kcal/mol

Dissociation entropy (TΔS^diss): 13.8 kcal/mol

Symmetry number: 2

PDBe Complex ID: PDB-CPX-128909

$Homo dimeric assembly 1 of PDB entry 6s1f coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Receptor-interacting serine/threonine-protein kinase 2;</li> <li class='image_legend_li'>2 copies of ~{N}-[3-[2-azanyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]-5-methoxy-phenyl]methanesulfonamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Homo dimeric assembly 1 of PDB entry 6s1f coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Receptor-interacting serine/threonine-protein kinase 2;</li> <li class='image_legend_li'>2 copies of ~{N}-[3-[2-azanyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]-5-methoxy-phenyl]methanesulfonamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Homo dimeric assembly 1 of PDB entry 6s1f coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Receptor-interacting serine/threonine-protein kinase 2;</li> <li class='image_legend_li'>2 copies of ~{N}-[3-[2-azanyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]-5-methoxy-phenyl]methanesulfonamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Assembly 2

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Assembly Name: Receptor-interacting serine/threonine-protein kinase 2
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Multimeric state: homo dimer

Accessible surface area: 25374.55 Å²

Buried surface area: 3545.55 Å²

Dissociation area: 1,772.77 Å²

Dissociation energy (ΔG^diss): 20.62 kcal/mol

Dissociation entropy (TΔS^diss): 13.75 kcal/mol

Symmetry number: 2

PDBe Complex ID: PDB-CPX-128909

$Homo dimeric assembly 2 of PDB entry 6s1f coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Receptor-interacting serine/threonine-protein kinase 2;</li> <li class='image_legend_li'>2 copies of ~{N}-[3-[2-azanyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]-5-methoxy-phenyl]methanesulfonamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Homo dimeric assembly 2 of PDB entry 6s1f coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Receptor-interacting serine/threonine-protein kinase 2;</li> <li class='image_legend_li'>2 copies of ~{N}-[3-[2-azanyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]-5-methoxy-phenyl]methanesulfonamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Homo dimeric assembly 2 of PDB entry 6s1f coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>2 copies of Receptor-interacting serine/threonine-protein kinase 2;</li> <li class='image_legend_li'>2 copies of ~{N}-[3-[2-azanyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]-5-methoxy-phenyl]methanesulfonamide;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Macromolecules

Receptor-interacting serine/threonine-protein kinase 2

Chains: A, B, C, D
Length: 317 amino acids
Theoretical weight: 36.39 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:

Canonical: O43353 (Residues: 3-317; Coverage: 58%)

Gene names: CARDIAK, RICK, RIP2, RIPK2, UNQ277/PRO314/PRO34092
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:

Protein kinase-like domain superfamily
Protein kinase domain
Serine-threonine/tyrosine-protein kinase, catalytic domain
Serine/threonine-protein kinase, active site

Receptor-interacting serine/threonine-protein kinase 2 in PDB entry 6s1f, assembly 1, front view.

Receptor-interacting serine/threonine-protein kinase 2 in PDB entry 6s1f, assembly 1, side view.

Receptor-interacting serine/threonine-protein kinase 2 in PDB entry 6s1f, assembly 1, top view.

FASTA Sequence


    >pdb|6s1f|A B C D

SMGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSV

PDBe-KB: UniProt Coverage View: O43353

Molecule details ›

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FASTA (Protein chains A, B, C, D)
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Structure Factors
SIFTS XML file with residue-level mappings

Search similar proteins

Similar 3D structures (PDBeFold)
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BLAST O43353 (UniProt)

Protein Data Bank in Europe

Structure of the kinase domain of human RIPK2 in complex with the inhibitor CSLP3

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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PDBe › 6s1f › Structure analysis

Structure of the kinase domain of human RIPK2 in complex with the inhibitor CSLP3

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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6s1f › Structure analysis