X-ray diffraction
3.11Å resolution

Structure of the kinase domain of human RIPK2 in complex with the inhibitor CSLP3

Source organism: Homo sapiens
Entry authors: Pinkas DM, Bufton JC, Kupinska K, Burgess-Brown NA, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Bullock AN

Function and Biology Details

Reactions catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Receptor-interacting serine/threonine-protein kinase 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 317 amino acids
Theoretical weight: 36.39 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: O43353 (Residues: 3-317; Coverage: 58%)
  • Best match: O43353-2 (Residues: 1-180)
Gene names: CARDIAK, RICK, RIP2, RIPK2, UNQ277/PRO314/PRO34092
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P41212
Unit cell:
a: 124.343Å b: 124.343Å c: 228.676Å
α: 90° β: 90° γ: 90°
R R work R free
0.256 0.254 0.3
Expression system: Spodoptera frugiperda