6rzb

Electron Microscopy
5Å resolution

Cryo-EM structure of mouse cytoplasmic dynein-1 microtubule binding domain bound to microtubules

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Tubulin alpha-1B chain Chain: A
Molecule details ›
Chain: A
Length: 437 amino acids
Theoretical weight: 48.68 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: Q2XVP4 (Residues: 1-437; Coverage: 97%)
Gene name: TUBA1B
Sequence domains:
Tubulin beta chain Chain: B
Molecule details ›
Chain: B
Length: 426 amino acids
Theoretical weight: 47.83 KDa
Source organism: Sus scrofa
UniProt:
  • Canonical: P02554 (Residues: 1-426; Coverage: 96%)
Sequence domains:
Cytoplasmic dynein 1 heavy chain 1 Chain: C
Molecule details ›
Chain: C
Length: 149 amino acids
Theoretical weight: 16.89 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9JHU4 (Residues: 3270-3418; Coverage: 3%)
Gene names: Dhc1, Dnch1, Dnchc1, Dyhc, Dync1h1

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-10061
Expression system: Escherichia coli