› 6rx1

X-ray diffraction
2.1Å resolution

Crystal structure of human syncytin 1 in post-fusion conformation

Released:
DOI: 10.2210/pdb6rx1/pdb
PDB entry 6rx1 coloured by chain, front view.
PDB entry 6rx1 coloured by chain, side view.
PDB entry 6rx1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
X-ray Structures of the Post-fusion 6-Helix Bundle of the Human Syncytins and their Functional Implications.
Ruigrok K, Vaney MC, Buchrieser J, Baquero E, Hellert J, Baron B, England P, Schwartz O, Rey FA, Backovic M
J Mol Biol 431 4922-4940 (2019)
PMID: 31711961

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194066 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protein Chain: A
Molecule details ›
Chain: A
Length: 108 amino acids
Theoretical weight: 12.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UQF0 (Residues: 342-435; Coverage: 18%)
Gene names: ERVW-1, ERVWE1

Ligands and Environments

2 bound ligands:
Ligand GOL 1 x GOL
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 2
Spacegroup: R32
Unit cell:
a: 50.416Å b: 50.416Å c: 260.199Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.217 0.216 0.242
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 citation in other articles

Human Endogenous Retrovirus Type W Envelope from Multiple Sclerosis Demyelinating Lesions Shows Unique Solubility and Antigenic Characteristics.
Charvet et al. (2021)
2 more

5 mentions without citation

A Frame-by-Frame Glance at Membrane Fusion Mechanisms: From Viral Infections to Fertilization.
Azimi et al. (2023)
4 more