6rwl

Electron Microscopy
3.36Å resolution

Function and Biology Details

Reactions catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexadecamer (preferred)
Entry contents:
3 distinct polypeptide molecules
2 distinct DNA molecules
Macromolecules (5 distinct):
Pol protein Chains: A, B, C, E, I, J, K, M
Molecule details ›
Chains: A, B, C, E, I, J, K, M
Length: 290 amino acids
Theoretical weight: 32.73 KDa
Source organism: Simian immunodeficiency virus
Expression system: Escherichia coli
UniProt:
  • Canonical: E1ANT8 (Residues: 735-1023; Coverage: 28%)
Gene name: pol
Sequence domains:
Pol protein Chains: D, L
Molecule details ›
Chains: D, L
Length: 289 amino acids
Theoretical weight: 32.68 KDa
Source organism: Simian immunodeficiency virus
Expression system: Escherichia coli
UniProt:
  • Canonical: E1ANT8 (Residues: 735-1023; Coverage: 28%)
Gene name: pol
Sequence domains:
Pol protein Chains: F, N
Molecule details ›
Chains: F, N
Length: 290 amino acids
Theoretical weight: 32.69 KDa
Source organism: Simian immunodeficiency virus
Expression system: Escherichia coli
UniProt:
  • Canonical: E1ANT8 (Residues: 735-1023; Coverage: 28%)
Gene name: pol
Sequence domains:
DNA (5'-D(P*GP*CP*TP*AP*AP*GP*AP*AP*AP*AP*AP*TP*CP*TP*CP*TP*AP*CP*CP*A)-3') Chains: T, W
Molecule details ›
Chains: T, W
Length: 30 nucleotides
Theoretical weight: 9.22 KDa
DNA (5'-D(*AP*AP*CP*TP*GP*GP*TP*AP*GP*AP*GP*AP*TP*TP*TP*TP*TP*CP*TP*TP*AP*GP*C)-3') Chains: Q, S
Molecule details ›
Chains: Q, S
Length: 33 nucleotides
Theoretical weight: 10.13 KDa

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.36Å
Relevant EMDB volumes: EMD-10041
Expression system: Escherichia coli