X-ray diffraction
2.1Å resolution

Thioredoxin glutathione reductase from Schistosoma mansoni in complex with 1-[(dimethylamino)methyl]-2-naphthol at 2 hour of soaking


Function and Biology Details

Reaction catalysed:
Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Glutaredoxin domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 598 amino acids
Theoretical weight: 65.11 KDa
Source organism: Schistosoma mansoni
Expression system: Escherichia coli
  • Canonical: G4V8J4 (Residues: 1-598; Coverage: 100%)
Gene name: Smp_048430
Sequence domains:

Ligands and Environments

Cofactor: Ligand FAD 1 x FAD
3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: C2
Unit cell:
a: 142.042Å b: 102.002Å c: 58.54Å
α: 90° β: 112.78° γ: 90°
R R work R free
0.186 0.184 0.234
Expression system: Escherichia coli