6rrk

X-ray diffraction
3.17Å resolution

Crystal structure of the central region of human cohesin subunit STAG1 in complex with RAD21 peptide

Released:
Source organism: Homo sapiens
Entry authors: Newman JA, katis VL, von Delft F, Arrowsmith CH, Edwards A, Bountra C, Gileadi O

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cohesin subunit SA-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 459 amino acids
Theoretical weight: 52.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WVM7 (Residues: 459-915; Coverage: 36%)
Gene names: SA1, SCC3, STAG1
64-kDa C-terminal product Chains: C, D
Molecule details ›
Chains: C, D
Length: 40 amino acids
Theoretical weight: 4.69 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O60216 (Residues: 356-395; Coverage: 6%)
Gene names: HR21, KIAA0078, NXP1, RAD21, SCC1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P21
Unit cell:
a: 74.333Å b: 86.29Å c: 118.585Å
α: 90° β: 95.36° γ: 90°
R-values:
R R work R free
0.222 0.219 0.278
Expression systems:
  • Escherichia coli
  • Not provided