Electron Microscopy
3.4Å resolution

Structure of PTCH1 bound to a modified Hedgehog ligand ShhN-C24II

Source organisms:
Related structures: EMD-4936

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
GFP-like fluorescent chromoprotein FP506, related; Protein patched homolog 1 Chain: A
Molecule details ›
Chain: A
Length: 1471 amino acids
Theoretical weight: 163.85 KDa
Source organisms: Expression system: Homo sapiens
  • Canonical: Q13635 (Residues: 1-1188; Coverage: 82%)
  • Canonical: U6GSR1 (Residues: 2-241; Coverage: 92%)
Gene names: EAH_00062270, PTCH, PTCH1
Sequence domains:
Sonic hedgehog protein N-product Chain: B
Molecule details ›
Chain: B
Length: 285 amino acids
Theoretical weight: 32.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
  • Canonical: Q15465 (Residues: 21-197; Coverage: 40%)
Gene name: SHH
Sequence domains: Hedgehog amino-terminal signalling domain

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.4Å
Relevant EMDB volumes: EMD-4936
Expression systems:
  • Homo sapiens
  • Escherichia coli BL21