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Trypanosoma brucei Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-sulfamoyl)cytidine

Source organism: Trypanosoma brucei gambiense
Biochemical function: ligase activity
Biological process: mitochondrial seryl-tRNA aminoacylation
Cellular component: cytosol

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EC 6.1.1.11: Serine--tRNA ligase

Reaction catalysed:
ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec)
Systematic name:
L-serine:tRNA(Ser) ligase (AMP-forming)
Alternative Name(s):
  • SerRS
  • Serine translase
  • Seryl-tRNA synthetase
  • Seryl-transfer RNA synthetase
  • Seryl-transfer ribonucleate synthetase
  • Seryl-transfer ribonucleic acid synthetase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00587
Domain description: tRNA synthetase class II core domain (G, H, P, S and T)
Occurring in:
  1. serine--tRNA ligase
The deposited structure of PDB entry 6rlu contains 2 copies of Pfam domain PF00587 (tRNA synthetase class II core domain (G, H, P, S and T)) in serine--tRNA ligase. Showing 1 copy in chain A.

PF02403
Domain description: Seryl-tRNA synthetase N-terminal domain
Occurring in:
  1. serine--tRNA ligase
The deposited structure of PDB entry 6rlu contains 2 copies of Pfam domain PF02403 (Seryl-tRNA synthetase N-terminal domain) in serine--tRNA ligase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002317
Domain description: Serine-tRNA ligase, type1
Occurring in:
  1. serine--tRNA ligase
IPR045864
Domain description: Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
Occurring in:
  1. serine--tRNA ligase
IPR010978
Domain description: Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm
Occurring in:
  1. serine--tRNA ligase
IPR002314
Domain description: Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
Occurring in:
  1. serine--tRNA ligase
IPR006195
Domain description: Aminoacyl-tRNA synthetase, class II
Occurring in:
  1. serine--tRNA ligase
IPR033729
Domain description: Serine-tRNA ligase catalytic core domain
Occurring in:
  1. serine--tRNA ligase
IPR015866
Domain description: Serine-tRNA synthetase, type1, N-terminal
Occurring in:
  1. serine--tRNA ligase
IPR042103
Domain description: Serine-tRNA synthetase, type1, N-terminal domain superfamily
Occurring in:
  1. serine--tRNA ligase

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