› 6rch

X-ray diffraction
1.45Å resolution

Crystal structure of Casein kinase I isoform delta (CK1 delta) complexed with SR4133 inhibitor

Released:
DOI: 10.2210/pdb6rch/pdb
PDB entry 6rch coloured by chain, front view.
PDB entry 6rch coloured by chain, side view.
PDB entry 6rch coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Chaikuad A, Arrowsmith CH, Edwards AM, Bountra C, Roush WR, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155798 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase I isoform delta Chains: A, B
Molecule details ›
Chains: A, B
Length: 296 amino acids
Theoretical weight: 34.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P48730 (Residues: 1-294; Coverage: 71%)
Gene names: CSNK1D, HCKID
Sequence domains: Protein kinase domain

Ligands and Environments

4 bound ligands:
Ligand SO4 7 x SO4
Ligand EDO 6 x EDO
Ligand NA 2 x NA
Ligand K0B 1 x K0B
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P21
Unit cell:
a: 49.106Å b: 74.072Å c: 88.967Å
α: 90° β: 103.18° γ: 90°
R-values:
R R work R free
0.157 0.155 0.178
Expression system: Escherichia coli

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