6rcg

X-ray diffraction
1.4Å resolution

Crystal structure of Casein kinase 1 delta (CK1 delta) complexed with SR3029 inhibitor

Released:
Source organism: Homo sapiens
Entry authors: Chaikuad A, Arrowsmith CH, Edwards AM, Bountra C, Roush WR, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed:
ATP + [tau protein] = ADP + [tau protein] phosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase I isoform delta Chain: A
Molecule details ›
Chain: A
Length: 296 amino acids
Theoretical weight: 34.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P48730 (Residues: 1-294; Coverage: 71%)
Gene names: CSNK1D, HCKID
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: C2
Unit cell:
a: 88.04Å b: 53.55Å c: 72.17Å
α: 90° β: 113.45° γ: 90°
R-values:
R R work R free
0.144 0.142 0.185
Expression system: Escherichia coli