› 6r5f

X-ray diffraction
3.25Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171747 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-interacting serine/threonine-protein kinase 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 303 amino acids
Theoretical weight: 34.6 KDa
Source organism: Homo sapiens
Expression system: Baculovirus expression vector pFastBac1-HM
UniProt:
  • Canonical: Q13546 (Residues: 1-294; Coverage: 44%)
Gene names: RIP, RIP1, RIPK1
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand JSW 4 x JSW
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P21
Unit cell:
a: 45.858Å b: 138.919Å c: 96.534Å
α: 90° β: 96.5° γ: 90°
R-values:
R R work R free
0.245 0.243 0.289
Expression system: Baculovirus expression vector pFastBac1-HM

Quick links

Citations

4 review citations

Cell death pathways: intricate connections and disease implications.
Kist et al. (2021)
3 more

2 mentions without citation

Advances in RIPK1 kinase inhibitors.
Chen et al. (2022)
1 more