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Crystal structure of human GFAT-1 in complex with Glucose-6-Phosphate and L-Glu

Source organism: Homo sapiens
Biochemical function: carbohydrate derivative binding
Biological process: carbohydrate derivative biosynthetic process
Cellular component: not assigned

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EC 2.6.1.16: Glutamine--fructose-6-phosphate transaminase (isomerizing)

Reaction catalysed:
L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate
Systematic name:
L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
Alternative Name(s):
  • D-fructose-6-phosphate amidotransferase
  • GlcN6P synthase
  • Glucosamine 6-phosphate synthase
  • Glucosamine-6-phosphate isomerase (glutamine-forming)
  • Glucosamine-6-phosphate synthase
  • Glucosaminephosphate isomerase
  • Hexosephosphate aminotransferase
  • L-glutamine-D-fructose-6-phosphate amidotransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF01380
Domain description: SIS domain
Occurring in:
  1. Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
The deposited structure of PDB entry 6r4e contains 4 copies of Pfam domain PF01380 (SIS domain) in Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1. Showing 2 copies in chain A.

PF13522
Domain description: Glutamine amidotransferase domain
Occurring in:
  1. Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
The deposited structure of PDB entry 6r4e contains 2 copies of Pfam domain PF13522 (Glutamine amidotransferase domain) in Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001347
Domain description: SIS domain
Occurring in:
  1. Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
IPR029055
Domain description: Nucleophile aminohydrolases, N-terminal
Occurring in:
  1. Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
IPR035490
Domain description: GlmS/FrlB, SIS domain 2
Occurring in:
  1. Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
IPR035466
Domain description: GlmS/AgaS, SIS domain 1
Occurring in:
  1. Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
IPR046348
Domain description: SIS domain superfamily
Occurring in:
  1. Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
IPR005855
Domain description: Glucosamine-fructose-6-phosphate aminotransferase, isomerising
Occurring in:
  1. Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
IPR047084
Domain description: Glucosamine-fructose-6-phosphate aminotransferase, isomerising, N-terminal domain
Occurring in:
  1. Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
IPR017932
Domain description: Glutamine amidotransferase type 2 domain
Occurring in:
  1. Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

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