6r4e

X-ray diffraction
2.35Å resolution

Crystal structure of human GFAT-1 in complex with Glucose-6-Phosphate and L-Glu

Released:

Function and Biology Details

Reaction catalysed:
L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 687 amino acids
Theoretical weight: 77.78 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q06210 (Residues: 1-317, 318-699; Coverage: 97%)
  • Best match: Q06210-2 (Residues: 1-299, 300-681)
Gene names: GFAT, GFPT, GFPT1
Sequence domains:

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P13 (MX1)
Spacegroup: P41212
Unit cell:
a: 153.847Å b: 153.847Å c: 166.292Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.174 0.21
Expression system: Spodoptera frugiperda