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Structure of a human fully-assembled precatalytic spliceosome (pre-B complex).

Electron Microscopy
3.28Å resolution
PDB entry 6qx9 coloured by chain, front view.
PDB entry 6qx9 coloured by chain, side view.
PDB entry 6qx9 coloured by chain, top view.
Source organisms:
Assembly composition:
hetero 71-mer (preferred)
Entry contents: 44 distinct polypeptide molecules
6 distinct RNA molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero 71-mer
PDBe Complex ID: PDB-CPX-243100

Macromolecules

U5 small nuclear ribonucleoprotein 40 kDa protein
Chain: 5O
Length: 357 amino acids
Theoretical weight: 39.36 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96DI7 (Residues: 1-357; Coverage: 100%)
Gene names: PRP8BP, SFP38, SNRNP40, WDR57
Pfam: WD domain, G-beta repeat
InterPro:
U5 small nuclear ribonucleoprotein 40 kDa protein in PDB entry 6qx9, assembly 1, front view.
U5 small nuclear ribonucleoprotein 40 kDa protein in PDB entry 6qx9, assembly 1, side view.
U5 small nuclear ribonucleoprotein 40 kDa protein in PDB entry 6qx9, assembly 1, top view.
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Splicing factor 3B subunit 4
Chain: B4
Length: 424 amino acids
Theoretical weight: 44.44 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q15427 (Residues: 1-424; Coverage: 100%)
Gene names: SAP49, SF3B4
Pfam: RNA recognition motif
InterPro:
Splicing factor 3B subunit 4 in PDB entry 6qx9, assembly 1, front view.
Splicing factor 3B subunit 4 in PDB entry 6qx9, assembly 1, side view.
Splicing factor 3B subunit 4 in PDB entry 6qx9, assembly 1, top view.
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Small nuclear ribonucleoprotein Sm D3
Chains: 13, 23, 43, 53
Length: 126 amino acids
Theoretical weight: 13.94 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62318 (Residues: 1-126; Coverage: 100%)
Gene name: SNRPD3
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein Sm D3 in PDB entry 6qx9, assembly 1, front view.
Small nuclear ribonucleoprotein Sm D3 in PDB entry 6qx9, assembly 1, side view.
Small nuclear ribonucleoprotein Sm D3 in PDB entry 6qx9, assembly 1, top view.
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U4/U6 small nuclear ribonucleoprotein Prp4
Chain: 4B
Length: 522 amino acids
Theoretical weight: 58.54 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O43172 (Residues: 1-522; Coverage: 100%)
Gene names: PRP4, PRPF4
Pfam:
InterPro:
U4/U6 small nuclear ribonucleoprotein Prp4 in PDB entry 6qx9, assembly 1, front view.
U4/U6 small nuclear ribonucleoprotein Prp4 in PDB entry 6qx9, assembly 1, side view.
U4/U6 small nuclear ribonucleoprotein Prp4 in PDB entry 6qx9, assembly 1, top view.
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Small nuclear ribonucleoprotein E
Chains: 1e, 2e, 4e, 5e
Length: 92 amino acids
Theoretical weight: 10.82 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62304 (Residues: 1-92; Coverage: 100%)
Gene name: SNRPE
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein E in PDB entry 6qx9, assembly 1, front view.
Small nuclear ribonucleoprotein E in PDB entry 6qx9, assembly 1, side view.
Small nuclear ribonucleoprotein E in PDB entry 6qx9, assembly 1, top view.
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U1 small nuclear ribonucleoprotein 70 kDa
Chain: 1K
Length: 437 amino acids
Theoretical weight: 51.68 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P08621 (Residues: 1-437; Coverage: 100%)
Gene names: RNPU1Z, RPU1, SNRNP70, SNRP70, U1AP1
Pfam:
InterPro:
U1 small nuclear ribonucleoprotein 70 kDa in PDB entry 6qx9, assembly 1, front view.
U1 small nuclear ribonucleoprotein 70 kDa in PDB entry 6qx9, assembly 1, side view.
U1 small nuclear ribonucleoprotein 70 kDa in PDB entry 6qx9, assembly 1, top view.
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U4/U6 small nuclear ribonucleoprotein Prp31
Chain: 4C
Length: 499 amino acids
Theoretical weight: 55.53 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8WWY3 (Residues: 1-499; Coverage: 100%)
Gene names: PRP31, PRPF31
Pfam:
InterPro:
U4/U6 small nuclear ribonucleoprotein Prp31 in PDB entry 6qx9, assembly 1, front view.
U4/U6 small nuclear ribonucleoprotein Prp31 in PDB entry 6qx9, assembly 1, side view.
U4/U6 small nuclear ribonucleoprotein Prp31 in PDB entry 6qx9, assembly 1, top view.
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Small nuclear ribonucleoprotein Sm D1
Chains: 11, 21, 41, 51
Length: 119 amino acids
Theoretical weight: 13.31 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62314 (Residues: 1-119; Coverage: 100%)
Gene name: SNRPD1
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein Sm D1 in PDB entry 6qx9, assembly 1, front view.
Small nuclear ribonucleoprotein Sm D1 in PDB entry 6qx9, assembly 1, side view.
Small nuclear ribonucleoprotein Sm D1 in PDB entry 6qx9, assembly 1, top view.
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RNA-binding protein 42
Chain: R
Length: 480 amino acids
Theoretical weight: 50.48 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BTD8 (Residues: 1-480; Coverage: 100%)
Gene name: RBM42
Pfam: RNA recognition motif
InterPro:
RNA-binding protein 42 in PDB entry 6qx9, assembly 1, front view.
RNA-binding protein 42 in PDB entry 6qx9, assembly 1, side view.
RNA-binding protein 42 in PDB entry 6qx9, assembly 1, top view.
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Small nuclear ribonucleoprotein F
Chains: 1f, 2f, 4f, 5f
Length: 86 amino acids
Theoretical weight: 9.73 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62306 (Residues: 1-86; Coverage: 100%)
Gene names: PBSCF, SNRPF
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein F in PDB entry 6qx9, assembly 1, front view.
Small nuclear ribonucleoprotein F in PDB entry 6qx9, assembly 1, side view.
Small nuclear ribonucleoprotein F in PDB entry 6qx9, assembly 1, top view.
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U6 snRNA-associated Sm-like protein LSm6
Chain: 66
Length: 80 amino acids
Theoretical weight: 9.14 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62312 (Residues: 1-80; Coverage: 100%)
Gene name: LSM6
Pfam: LSM domain
InterPro:
U6 snRNA-associated Sm-like protein LSm6 in PDB entry 6qx9, assembly 1, front view.
U6 snRNA-associated Sm-like protein LSm6 in PDB entry 6qx9, assembly 1, side view.
U6 snRNA-associated Sm-like protein LSm6 in PDB entry 6qx9, assembly 1, top view.
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U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein
Chain: X
Length: 155 amino acids
Theoretical weight: 18.92 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8WVK2 (Residues: 1-155; Coverage: 100%)
Gene name: SNRNP27
Pfam: U4/U6.U5 small nuclear ribonucleoproteins
InterPro: U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein in PDB entry 6qx9, assembly 1, front view.
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein in PDB entry 6qx9, assembly 1, side view.
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein in PDB entry 6qx9, assembly 1, top view.
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Small nuclear ribonucleoprotein Sm D2
Chains: 12, 22, 42, 52
Length: 118 amino acids
Theoretical weight: 13.55 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62316 (Residues: 1-118; Coverage: 100%)
Gene names: SNRPD1, SNRPD2
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein Sm D2 in PDB entry 6qx9, assembly 1, front view.
Small nuclear ribonucleoprotein Sm D2 in PDB entry 6qx9, assembly 1, side view.
Small nuclear ribonucleoprotein Sm D2 in PDB entry 6qx9, assembly 1, top view.
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U6 snRNA-associated Sm-like protein LSm7
Chain: 67
Length: 103 amino acids
Theoretical weight: 11.62 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9UK45 (Residues: 1-103; Coverage: 100%)
Gene name: LSM7
Pfam: LSM domain
InterPro:
U6 snRNA-associated Sm-like protein LSm7 in PDB entry 6qx9, assembly 1, front view.
U6 snRNA-associated Sm-like protein LSm7 in PDB entry 6qx9, assembly 1, side view.
U6 snRNA-associated Sm-like protein LSm7 in PDB entry 6qx9, assembly 1, top view.
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U6 snRNA-associated Sm-like protein LSm2
Chain: 62
Length: 95 amino acids
Theoretical weight: 10.85 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y333 (Residues: 1-95; Coverage: 100%)
Gene names: C6orf28, G7B, LSM2
Pfam: LSM domain
InterPro:
U6 snRNA-associated Sm-like protein LSm2 in PDB entry 6qx9, assembly 1, front view.
U6 snRNA-associated Sm-like protein LSm2 in PDB entry 6qx9, assembly 1, side view.
U6 snRNA-associated Sm-like protein LSm2 in PDB entry 6qx9, assembly 1, top view.
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U2 small nuclear ribonucleoprotein B''
Chain: 2B
Length: 225 amino acids
Theoretical weight: 25.52 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P08579 (Residues: 1-225; Coverage: 100%)
Gene name: SNRPB2
Pfam: RNA recognition motif
InterPro:
U2 small nuclear ribonucleoprotein B'' in PDB entry 6qx9, assembly 1, front view.
U2 small nuclear ribonucleoprotein B'' in PDB entry 6qx9, assembly 1, side view.
U2 small nuclear ribonucleoprotein B'' in PDB entry 6qx9, assembly 1, top view.
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Splicing factor 3A subunit 2
Chain: A2
Length: 209 amino acids
Theoretical weight: 24.34 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q15428 (Residues: 1-209; Coverage: 45%)
Gene names: SAP62, SF3A2
Pfam:
InterPro:
Splicing factor 3A subunit 2 in PDB entry 6qx9, assembly 1, front view.
Splicing factor 3A subunit 2 in PDB entry 6qx9, assembly 1, side view.
Splicing factor 3A subunit 2 in PDB entry 6qx9, assembly 1, top view.
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Splicing factor 3B subunit 2
Chain: B2
Length: 895 amino acids
Theoretical weight: 100.38 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q13435 (Residues: 1-895; Coverage: 100%)
Gene names: SAP145, SF3B2
Pfam:
InterPro:
Splicing factor 3B subunit 2 in PDB entry 6qx9, assembly 1, front view.
Splicing factor 3B subunit 2 in PDB entry 6qx9, assembly 1, side view.
Splicing factor 3B subunit 2 in PDB entry 6qx9, assembly 1, top view.
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116 kDa U5 small nuclear ribonucleoprotein component
Chain: 5C
Length: 854 amino acids
Theoretical weight: 95.97 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q15029 (Residues: 104-957; Coverage: 88%)
Gene names: EFTUD2, KIAA0031, SNRP116
Pfam:
InterPro:
116 kDa U5 small nuclear ribonucleoprotein component in PDB entry 6qx9, assembly 1, front view.
116 kDa U5 small nuclear ribonucleoprotein component in PDB entry 6qx9, assembly 1, side view.
116 kDa U5 small nuclear ribonucleoprotein component in PDB entry 6qx9, assembly 1, top view.
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Probable ATP-dependent RNA helicase DDX23
Chain: 5X
Length: 820 amino acids
Theoretical weight: 95.79 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q9BUQ8 (Residues: 1-820; Coverage: 100%)
Gene name: DDX23
Pfam:
InterPro:
Probable ATP-dependent RNA helicase DDX23 in PDB entry 6qx9, assembly 1, front view.
Probable ATP-dependent RNA helicase DDX23 in PDB entry 6qx9, assembly 1, side view.
Probable ATP-dependent RNA helicase DDX23 in PDB entry 6qx9, assembly 1, top view.
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Small nuclear ribonucleoprotein-associated proteins B and B'
Chains: 1b, 2b, 4b, 5b
Length: 240 amino acids
Theoretical weight: 24.64 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P14678 (Residues: 1-240; Coverage: 100%)
Gene names: COD, SNRPB, SNRPB1
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein-associated proteins B and B' in PDB entry 6qx9, assembly 1, front view.
Small nuclear ribonucleoprotein-associated proteins B and B' in PDB entry 6qx9, assembly 1, side view.
Small nuclear ribonucleoprotein-associated proteins B and B' in PDB entry 6qx9, assembly 1, top view.
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Splicing factor 3B subunit 5
Chain: B5
Length: 86 amino acids
Theoretical weight: 10.15 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BWJ5 (Residues: 1-86; Coverage: 100%)
Gene names: SF3B10, SF3B5
Pfam: Splicing factor 3B subunit 10 (SF3b10)
InterPro:
Splicing factor 3B subunit 5 in PDB entry 6qx9, assembly 1, front view.
Splicing factor 3B subunit 5 in PDB entry 6qx9, assembly 1, side view.
Splicing factor 3B subunit 5 in PDB entry 6qx9, assembly 1, top view.
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U1 small nuclear ribonucleoprotein A
Chain: 1A
Length: 282 amino acids
Theoretical weight: 31.32 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P09012 (Residues: 1-282; Coverage: 100%)
Gene name: SNRPA
Pfam: RNA recognition motif
InterPro:
U1 small nuclear ribonucleoprotein A in PDB entry 6qx9, assembly 1, front view.
U1 small nuclear ribonucleoprotein A in PDB entry 6qx9, assembly 1, side view.
U1 small nuclear ribonucleoprotein A in PDB entry 6qx9, assembly 1, top view.
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U4/U6.U5 tri-snRNP-associated protein 1
Chain: S
Length: 800 amino acids
Theoretical weight: 90.41 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O43290 (Residues: 1-800; Coverage: 100%)
Gene name: SART1
Pfam:
InterPro:
U4/U6.U5 tri-snRNP-associated protein 1 in PDB entry 6qx9, assembly 1, front view.
U4/U6.U5 tri-snRNP-associated protein 1 in PDB entry 6qx9, assembly 1, side view.
U4/U6.U5 tri-snRNP-associated protein 1 in PDB entry 6qx9, assembly 1, top view.
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Pre-mRNA-processing factor 6
Chain: 5J
Length: 850 amino acids
Theoretical weight: 97 KDa
Source organisms: UniProt:
  • Canonical: Q91YR7 (Residues: 18-655; Coverage: 60%)
  • Canonical: O94906 (Residues: 656-937; Coverage: 30%)
    • nullnull
Gene names: C20orf14, PRPF6, Prpf6
Pfam:
InterPro:
Pre-mRNA-processing factor 6 in PDB entry 6qx9, assembly 1, front view.
Pre-mRNA-processing factor 6 in PDB entry 6qx9, assembly 1, side view.
Pre-mRNA-processing factor 6 in PDB entry 6qx9, assembly 1, top view.
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NHP2-like protein 1
Chain: 4D
Length: 128 amino acids
Theoretical weight: 14.19 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P55769 (Residues: 1-128; Coverage: 100%)
Gene names: NHP2L1, SNU13
Pfam: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
InterPro:
NHP2-like protein 1 in PDB entry 6qx9, assembly 1, front view.
NHP2-like protein 1 in PDB entry 6qx9, assembly 1, side view.
NHP2-like protein 1 in PDB entry 6qx9, assembly 1, top view.
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U6 snRNA-associated Sm-like protein LSm3
Chain: 63
Length: 102 amino acids
Theoretical weight: 11.86 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62310 (Residues: 1-102; Coverage: 100%)
Gene names: LSM3, MDS017
Pfam: LSM domain
InterPro:
U6 snRNA-associated Sm-like protein LSm3 in PDB entry 6qx9, assembly 1, front view.
U6 snRNA-associated Sm-like protein LSm3 in PDB entry 6qx9, assembly 1, side view.
U6 snRNA-associated Sm-like protein LSm3 in PDB entry 6qx9, assembly 1, top view.
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Splicing factor 3B subunit 3
Chain: B3
Length: 1217 amino acids
Theoretical weight: 135.72 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q15393 (Residues: 1-1217; Coverage: 100%)
Gene names: KIAA0017, SAP130, SF3B3
Pfam:
InterPro:
Splicing factor 3B subunit 3 in PDB entry 6qx9, assembly 1, front view.
Splicing factor 3B subunit 3 in PDB entry 6qx9, assembly 1, side view.
Splicing factor 3B subunit 3 in PDB entry 6qx9, assembly 1, top view.
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Small nuclear ribonucleoprotein G
Chains: 1g, 2g, 4g, 5g
Length: 76 amino acids
Theoretical weight: 8.51 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62308 (Residues: 1-76; Coverage: 100%)
Gene names: PBSCG, SNRPG
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein G in PDB entry 6qx9, assembly 1, front view.
Small nuclear ribonucleoprotein G in PDB entry 6qx9, assembly 1, side view.
Small nuclear ribonucleoprotein G in PDB entry 6qx9, assembly 1, top view.
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U6 snRNA-associated Sm-like protein LSm8
Chain: 68
Length: 96 amino acids
Theoretical weight: 10.41 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O95777 (Residues: 1-96; Coverage: 100%)
Gene name: LSM8
Pfam: LSM domain
InterPro:
U6 snRNA-associated Sm-like protein LSm8 in PDB entry 6qx9, assembly 1, front view.
U6 snRNA-associated Sm-like protein LSm8 in PDB entry 6qx9, assembly 1, side view.
U6 snRNA-associated Sm-like protein LSm8 in PDB entry 6qx9, assembly 1, top view.
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Pre-mRNA-processing-splicing factor 8
Chain: 5A
Length: 2311 amino acids
Theoretical weight: 271.51 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q6P2Q9 (Residues: 25-2335; Coverage: 99%)
Gene names: PRPC8, PRPF8
Pfam:
InterPro:
Pre-mRNA-processing-splicing factor 8 in PDB entry 6qx9, assembly 1, front view.
Pre-mRNA-processing-splicing factor 8 in PDB entry 6qx9, assembly 1, side view.
Pre-mRNA-processing-splicing factor 8 in PDB entry 6qx9, assembly 1, top view.
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Splicing factor 3A subunit 3
Chain: A3
Length: 501 amino acids
Theoretical weight: 58.93 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q12874 (Residues: 1-501; Coverage: 100%)
Gene names: SAP61, SF3A3
Pfam:
InterPro:
Splicing factor 3A subunit 3 in PDB entry 6qx9, assembly 1, front view.
Splicing factor 3A subunit 3 in PDB entry 6qx9, assembly 1, side view.
Splicing factor 3A subunit 3 in PDB entry 6qx9, assembly 1, top view.
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Ubiquitin carboxyl-terminal hydrolase 39
Chain: U
Length: 555 amino acids
Theoretical weight: 64.41 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q53GS9 (Residues: 1-555; Coverage: 98%)
Gene names: CGI-21, HSPC332, PRO2855, USP39
Pfam:
InterPro:
Ubiquitin carboxyl-terminal hydrolase 39 in PDB entry 6qx9, assembly 1, front view.
Ubiquitin carboxyl-terminal hydrolase 39 in PDB entry 6qx9, assembly 1, side view.
Ubiquitin carboxyl-terminal hydrolase 39 in PDB entry 6qx9, assembly 1, top view.
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Thioredoxin-like protein 4A
Chain: 5D
Length: 142 amino acids
Theoretical weight: 16.81 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P83876 (Residues: 1-142; Coverage: 100%)
Gene names: DIM1, TXNL4, TXNL4A
Pfam: Mitosis protein DIM1
InterPro:
Thioredoxin-like protein 4A in PDB entry 6qx9, assembly 1, front view.
Thioredoxin-like protein 4A in PDB entry 6qx9, assembly 1, side view.
Thioredoxin-like protein 4A in PDB entry 6qx9, assembly 1, top view.
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U6 snRNA-associated Sm-like protein LSm4
Chain: 64
Length: 139 amino acids
Theoretical weight: 15.38 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y4Z0 (Residues: 1-139; Coverage: 100%)
Gene name: LSM4
Pfam: LSM domain
InterPro:
U6 snRNA-associated Sm-like protein LSm4 in PDB entry 6qx9, assembly 1, front view.
U6 snRNA-associated Sm-like protein LSm4 in PDB entry 6qx9, assembly 1, side view.
U6 snRNA-associated Sm-like protein LSm4 in PDB entry 6qx9, assembly 1, top view.
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PHD finger-like domain-containing protein 5A
Chain: BP
Length: 104 amino acids
Theoretical weight: 11.64 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q7RTV0 (Residues: 1-104; Coverage: 95%)
Gene name: PHF5A
Pfam: PHF5-like protein
InterPro: PHF5-like
PHD finger-like domain-containing protein 5A in PDB entry 6qx9, assembly 1, front view.
PHD finger-like domain-containing protein 5A in PDB entry 6qx9, assembly 1, side view.
PHD finger-like domain-containing protein 5A in PDB entry 6qx9, assembly 1, top view.
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U1 small nuclear ribonucleoprotein C
Chain: 1C
Length: 159 amino acids
Theoretical weight: 17.42 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P09234 (Residues: 1-159; Coverage: 100%)
Gene name: SNRPC
Pfam: U1 zinc finger
InterPro:
U1 small nuclear ribonucleoprotein C in PDB entry 6qx9, assembly 1, front view.
U1 small nuclear ribonucleoprotein C in PDB entry 6qx9, assembly 1, side view.
U1 small nuclear ribonucleoprotein C in PDB entry 6qx9, assembly 1, top view.
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Serine/threonine-protein kinase PRP4 homolog
Chain: K
Length: 1007 amino acids
Theoretical weight: 117.26 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q13523 (Residues: 1-1007; Coverage: 100%)
Gene names: KIAA0536, PRP4, PRP4B, PRP4H, PRP4K, PRPF4K
Pfam: Protein kinase domain
InterPro:
Serine/threonine-protein kinase PRP4 homolog in PDB entry 6qx9, assembly 1, front view.
Serine/threonine-protein kinase PRP4 homolog in PDB entry 6qx9, assembly 1, side view.
Serine/threonine-protein kinase PRP4 homolog in PDB entry 6qx9, assembly 1, top view.
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U4/U6 small nuclear ribonucleoprotein Prp3
Chain: 4A
Length: 683 amino acids
Theoretical weight: 77.67 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O43395 (Residues: 1-683; Coverage: 100%)
Gene names: HPRP3, PRP3, PRPF3
Pfam:
InterPro:
U4/U6 small nuclear ribonucleoprotein Prp3 in PDB entry 6qx9, assembly 1, front view.
U4/U6 small nuclear ribonucleoprotein Prp3 in PDB entry 6qx9, assembly 1, side view.
U4/U6 small nuclear ribonucleoprotein Prp3 in PDB entry 6qx9, assembly 1, top view.
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U2 small nuclear ribonucleoprotein A'
Chain: 2A
Length: 255 amino acids
Theoretical weight: 28.46 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P09661 (Residues: 1-255; Coverage: 100%)
Gene name: SNRPA1
Pfam: Leucine-rich repeat
InterPro:
U2 small nuclear ribonucleoprotein A' in PDB entry 6qx9, assembly 1, front view.
U2 small nuclear ribonucleoprotein A' in PDB entry 6qx9, assembly 1, side view.
U2 small nuclear ribonucleoprotein A' in PDB entry 6qx9, assembly 1, top view.
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Splicing factor 3A subunit 1
Chain: A1
Length: 647 amino acids
Theoretical weight: 71.62 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q15459 (Residues: 1-793; Coverage: 82%)
Gene names: SAP114, SF3A1
Pfam:
InterPro:
Splicing factor 3A subunit 1 in PDB entry 6qx9, assembly 1, front view.
Splicing factor 3A subunit 1 in PDB entry 6qx9, assembly 1, side view.
Splicing factor 3A subunit 1 in PDB entry 6qx9, assembly 1, top view.
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U6 snRNA-associated Sm-like protein LSm5
Chain: 65
Length: 91 amino acids
Theoretical weight: 9.95 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y4Y9 (Residues: 1-91; Coverage: 100%)
Gene name: LSM5
Pfam: LSM domain
InterPro:
U6 snRNA-associated Sm-like protein LSm5 in PDB entry 6qx9, assembly 1, front view.
U6 snRNA-associated Sm-like protein LSm5 in PDB entry 6qx9, assembly 1, side view.
U6 snRNA-associated Sm-like protein LSm5 in PDB entry 6qx9, assembly 1, top view.
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U5 small nuclear ribonucleoprotein 200 kDa helicase
Chain: 5B
Length: 2136 amino acids
Theoretical weight: 244.82 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O75643 (Residues: 1-2136; Coverage: 100%)
Gene names: ASCC3L1, BRR2, HELIC2, KIAA0788, SNRNP200
Pfam:
InterPro:
U5 small nuclear ribonucleoprotein 200 kDa helicase in PDB entry 6qx9, assembly 1, front view.
U5 small nuclear ribonucleoprotein 200 kDa helicase in PDB entry 6qx9, assembly 1, side view.
U5 small nuclear ribonucleoprotein 200 kDa helicase in PDB entry 6qx9, assembly 1, top view.
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Splicing factor 3B subunit 1
Chain: B1
Length: 1304 amino acids
Theoretical weight: 146.02 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O75533 (Residues: 1-1304; Coverage: 100%)
Gene names: SAP155, SF3B1
Pfam: Splicing factor 3B subunit 1
InterPro:
Splicing factor 3B subunit 1 in PDB entry 6qx9, assembly 1, front view.
Splicing factor 3B subunit 1 in PDB entry 6qx9, assembly 1, side view.
Splicing factor 3B subunit 1 in PDB entry 6qx9, assembly 1, top view.
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RNA chain 1
Name: U1 snRNA
Representative chains: 1
Length: 164 nucleotides
Theoretical weight: 52.7 KDa
Rfam: U1 spliceosomal RNA
U1 snRNA in PDB entry 6qx9, assembly 1, front view.
U1 snRNA in PDB entry 6qx9, assembly 1, side view.
U1 snRNA in PDB entry 6qx9, assembly 1, top view.
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RNA chain 6
Name: U6 snRNA
Representative chains: 6
Length: 106 nucleotides
Theoretical weight: 34.1 KDa
Rfam: U6 spliceosomal RNA
U6 snRNA in PDB entry 6qx9, assembly 1, front view.
U6 snRNA in PDB entry 6qx9, assembly 1, side view.
U6 snRNA in PDB entry 6qx9, assembly 1, top view.
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RNA chain I
Name: AdML pre-mRNA
Representative chains: I
Length: 62 nucleotides
Theoretical weight: 15.28 KDa
AdML pre-mRNA in PDB entry 6qx9, assembly 1, front view.
AdML pre-mRNA in PDB entry 6qx9, assembly 1, side view.
AdML pre-mRNA in PDB entry 6qx9, assembly 1, top view.
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RNA chain 5
Name: U5 snRNA
Representative chains: 5
Length: 117 nucleotides
Theoretical weight: 37.25 KDa
Rfam: U5 spliceosomal RNA
U5 snRNA in PDB entry 6qx9, assembly 1, front view.
U5 snRNA in PDB entry 6qx9, assembly 1, side view.
U5 snRNA in PDB entry 6qx9, assembly 1, top view.
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RNA chain 2
Name: U2 snRNA
Representative chains: 2
Length: 188 nucleotides
Theoretical weight: 60.17 KDa
Rfam: U2 spliceosomal RNA
U2 snRNA in PDB entry 6qx9, assembly 1, front view.
U2 snRNA in PDB entry 6qx9, assembly 1, side view.
U2 snRNA in PDB entry 6qx9, assembly 1, top view.
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RNA chain 4
Name: U4 snRNA
Representative chains: 4
Length: 146 nucleotides
Theoretical weight: 47 KDa
Rfam: U4 spliceosomal RNA
U4 snRNA in PDB entry 6qx9, assembly 1, front view.
U4 snRNA in PDB entry 6qx9, assembly 1, side view.
U4 snRNA in PDB entry 6qx9, assembly 1, top view.
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