› 6qvc

Electron Microscopy
4Å resolution

CryoEM structure of the human ClC-1 chloride channel, CBS state 1

Released:
DOI: 10.2210/pdb6qvc/pdb
PDB entry 6qvc coloured by chain, front view.
PDB entry 6qvc coloured by chain, side view.
PDB entry 6qvc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the human ClC-1 chloride channel.
Wang K, Preisler SS, Zhang L, Cui Y, Missel JW, Grønberg C, Gotfryd K, Lindahl E, Andersson M, Calloe K, Egea PF, Klaerke DA, Pusch M, Pedersen PA, Zhou ZH, Gourdon P
PLoS Biol 17 e3000218 (2019)
PMID: 31022181
Related structures: EMD-4647

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152936 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chloride channel protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 988 amino acids
Theoretical weight: 108.73 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P35523 (Residues: 1-988; Coverage: 100%)
Gene names: CLC1, CLCN1
Sequence domains: Voltage gated chloride channel

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4Å
Relevant EMDB volumes: EMD-4647
Expression system: Saccharomyces cerevisiae

Quick links

Citations

7 review citations

Changes in Membrane Protein Structural Biology.
Birch et al. (2020)
6 more

4 mentions without citation

Defective Gating and Proteostasis of Human ClC-1 Chloride Channel: Molecular Pathophysiology of Myotonia Congenita.
Jeng et al. (2020)
3 more