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Crystal structure of Spindlin1 in complex with the inhibitor MS31

X-ray diffraction
1.6Å resolution
PDB entry 6qpl coloured by chain, front view.
PDB entry 6qpl coloured by chain, side view.
PDB entry 6qpl coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Spindlin-1
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Multimeric state: monomeric
Accessible surface area: 10872.07 Å2
Buried surface area: 1290.4 Å2
Dissociation area: 70.14 Å2
Dissociation energy (ΔGdiss): -1.77 kcal/mol
Dissociation entropy (TΔSdiss): 0.39 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-195334

Macromolecules

Spindlin-1
Chain: B
Length: 222 amino acids
Theoretical weight: 25.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y657 (Residues: 48-262; Coverage: 82%)
Gene names: OCR, SPIN, SPIN1
Pfam: Spin/Ssty Family
InterPro:
Spindlin-1 in PDB entry 6qpl, assembly 1, front view.
Spindlin-1 in PDB entry 6qpl, assembly 1, side view.
Spindlin-1 in PDB entry 6qpl, assembly 1, top view.
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