› 6qlx

X-ray diffraction
2.1Å resolution

Cathepsin-K in complex with fluoro-oxa-azabicyclo[3.3.0]octanyl containing inhibitor

Released:
DOI: 10.2210/pdb6qlx/pdb
PDB entry 6qlx coloured by chain, front view.
PDB entry 6qlx coloured by chain, side view.
PDB entry 6qlx coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Derbyshire DJ

Function and Biology Details

Reaction catalysed: 
Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154996 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cathepsin K Chain: A
Molecule details ›
Chain: A
Length: 216 amino acids
Theoretical weight: 23.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P43235 (Residues: 114-329; Coverage: 69%)
Gene names: CTSK, CTSO, CTSO2
Sequence domains: Papain family cysteine protease

Ligands and Environments

1 bound ligand:
Ligand HKH 1 x HKH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS
Spacegroup: P43
Unit cell:
a: 71.204Å b: 71.204Å c: 54.541Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.186 0.237
Expression system: Escherichia coli

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