› 6qd5

X-ray diffraction
2.4Å resolution

X-ray Structure of the Human Urea Channel SLC14A1/UT1

Released:
DOI: 10.2210/pdb6qd5/pdb
PDB entry 6qd5 coloured by chain, front view.
PDB entry 6qd5 coloured by chain, side view.
PDB entry 6qd5 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dietz L, Chi G, Pike ACW, Moreau C, Man H, Snee M, Scacioc A, Shrestha L, Mukhopadhyay SMM, Mckinley G, Ellis K, Kliszcak M, Chalk R, Borkowska O, Burgess-Brown NA, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Durr KL, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171646 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Urea transporter 1 Chain: A
Molecule details ›
Chain: A
Length: 367 amino acids
Theoretical weight: 40.18 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q13336 (Residues: 31-389; Coverage: 92%)
Gene names: HUT11, JK, RACH1, SLC14A1, UT1, UTE
Sequence domains: Urea transporter
Structure domains: Ammonium transporter AmtB like domains

Ligands and Environments

3 bound ligands:
Ligand BOG 7 x BOG
Ligand Y01 1 x Y01
Ligand PG4 2 x PG4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P63
Unit cell:
a: 112.331Å b: 112.331Å c: 87.94Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.178 0.175 0.225
Expression system: Homo sapiens

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