6q82

X-ray diffraction
2.99Å resolution

Crystal structure of the biportin Pdr6 in complex with RanGTP

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Importin beta-like protein KAP122 Chain: A
Molecule details ›
Chain: A
Length: 1080 amino acids
Theoretical weight: 124.71 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli
UniProt:
  • Canonical: P32767 (Residues: 2-1081; Coverage: 100%)
Gene names: KAP122, PDR6, YGL016W
GTP-binding nuclear protein Ran Chain: B
Molecule details ›
Chain: B
Length: 176 amino acids
Theoretical weight: 20.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62826 (Residues: 5-180; Coverage: 82%)
Gene names: ARA24, OK/SW-cl.81, RAN
Sequence domains: Ras family

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P6322
Unit cell:
a: 192.99Å b: 192.99Å c: 229.17Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.219 0.218 0.253
Expression system: Escherichia coli