› 6q42

X-ray diffraction
1.9Å resolution

Crystal Structure of Human Pancreatic Phospholipase A2

Released:
DOI: 10.2210/pdb6q42/pdb
PDB entry 6q42 coloured by chain, front view.
PDB entry 6q42 coloured by chain, side view.
PDB entry 6q42 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in HIV-infected patients.
Pothlichet J, Rose T, Bugault F, Jeammet L, Meola A, Haouz A, Saul F, Geny D, Alcami J, Ruiz-Mateos E, Teyton L, Lambeau G, Thèze J
J Clin Invest 130 2872-2887 (2020)
PMID: 32436864

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-137370 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phospholipase A2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 126 amino acids
Theoretical weight: 14.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04054 (Residues: 23-148; Coverage: 95%)
Gene names: PLA2, PLA2A, PLA2G1B, PPLA2
Sequence domains: Phospholipase A2

Ligands and Environments

1 bound ligand:
Ligand CL 4 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P212121
Unit cell:
a: 30.61Å b: 58.951Å c: 122.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.175 0.225
Expression system: Escherichia coli

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Citations

3 review citations

Updating Phospholipase A2 Biology.
Murakami et al. (2020)
2 more

1 mention without citation

PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in HIV-infected patients.
Pothlichet et al. (2020)