6q0k

Electron Microscopy
6.8Å resolution

Structure of a MAPK pathway complex

Released:
Source organism: Homo sapiens
Entry authors: Park E, Rawson S, Jeon H, Eck MJ
Related structures: EMD-20551

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine/threonine-protein kinase B-raf Chains: A, B
Molecule details ›
Chains: A, B
Length: 805 amino acids
Theoretical weight: 89.32 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P15056 (Residues: 1-766; Coverage: 100%)
Gene names: BRAF, BRAF1, RAFB1
Sequence domains:
14-3-3 protein zeta/delta Chains: X, Y
Molecule details ›
Chains: X, Y
Length: 245 amino acids
Theoretical weight: 27.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P63104 (Residues: 1-245; Coverage: 100%)
Gene name: YWHAZ
Sequence domains: 14-3-3 protein

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
Resolution: 6.8Å
Relevant EMDB volumes: EMD-20551
Expression system: Homo sapiens