6pwc

Electron Microscopy
4.9Å resolution

A complex structure of arrestin-2 bound to neurotensin receptor 1

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Neurotensin receptor type 1 Chain: R
Molecule details ›
Chain: R
Length: 370 amino acids
Theoretical weight: 41.56 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P30989 (Residues: 49-418; Coverage: 89%)
Gene names: NTRR, NTSR1
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Neurotensin peptide Chain: B
Molecule details ›
Chain: B
Length: 6 amino acids
Theoretical weight: 819 Da
Source organism: synthetic construct
Expression system: Not provided
Beta-arrestin-1 Chain: A
Molecule details ›
Chain: A
Length: 393 amino acids
Theoretical weight: 44.16 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P49407 (Residues: 1-393; Coverage: 94%)
Gene names: ARR1, ARRB1
Sequence domains:
Fab30 heavy chain Chain: H
Molecule details ›
Chain: H
Length: 238 amino acids
Theoretical weight: 25.69 KDa
Source organism: synthetic construct
Expression system: Spodoptera frugiperda
Fab30 light chain Chain: L
Molecule details ›
Chain: L
Length: 215 amino acids
Theoretical weight: 23.44 KDa
Source organism: synthetic construct
Expression system: Spodoptera frugiperda

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.9Å
Relevant EMDB volumes: EMD-20505
Expression systems:
  • Spodoptera frugiperda
  • Not provided