6puu

Electron Microscopy
3.7Å resolution

Human TRPM2 bound to 8-Br-cADPR and calcium

Released:
Source organism: Homo sapiens
Related structures: EMD-20482

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily M member 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1512 amino acids
Theoretical weight: 172.28 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O94759 (Residues: 1-1503; Coverage: 100%)
Gene names: EREG1, KNP3, LTRPC2, TRPC7, TRPM2
Sequence domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.7Å
Relevant EMDB volumes: EMD-20482
Expression system: Homo sapiens