› 6pez

Solid-state NMR

SOLID-STATE NMR STRUCTURE OF PISCIDIN 3 IN ALIGNED 4:1 PHOSPHATIDYLCHOLINE/CHOLESTEROL LIPID BILAYERS

Released:
DOI: 10.2210/pdb6pez/pdb
PDB entry 6pez coloured by chain, ensemble of 10 models, front view.
PDB entry 6pez coloured by chain, ensemble of 10 models, side view.
PDB entry 6pez coloured by chain, ensemble of 10 models, top view.
Source organism: Morone chrysops x Morone saxatilis
Primary publication:
The host-defense peptide piscidin P1 reorganizes lipid domains in membranes and decreases activation energies in mechanosensitive ion channels.
Comert F, Greenwood A, Maramba J, Acevedo R, Lucas L, Kulasinghe T, Cairns LS, Wen Y, Fu R, Hammer J, Blazyk J, Sukharev S, Cotten ML, Mihailescu M
J Biol Chem 294 18557-18570 (2019)
PMID: 31619519

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142849 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Piscidin-3 Chain: A
Molecule details ›
Chain: A
Length: 23 amino acids
Theoretical weight: 2.5 KDa
Source organism: Morone chrysops x Morone saxatilis
Expression system: Not provided
UniProt:
  • Canonical: P0C006 (Residues: 1-22; Coverage: 100%)
Sequence domains: Pleurocidin family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 6%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

3 review citations

Roles of Bacterial Mechanosensitive Channels in Infection and Antibiotic Susceptibility.
Sidarta et al. (2022)
2 more

2 mentions without citation

The host-defense peptide piscidin P1 reorganizes lipid domains in membranes and decreases activation energies in mechanosensitive ion channels.
Comert et al. (2019)
1 more