6pe8

X-ray diffraction
2.84Å resolution

Crystal structure of CD40/ABBV-323 FAB complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
FAB Heavy chain Chains: A, H
Molecule details ›
Chains: A, H
Length: 223 amino acids
Theoretical weight: 23.75 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
FAB Light chain Chains: B, L
Molecule details ›
Chains: B, L
Length: 220 amino acids
Theoretical weight: 24.29 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Tumor necrosis factor receptor superfamily member 5 Chains: T, U
Molecule details ›
Chains: T, U
Length: 173 amino acids
Theoretical weight: 19.19 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P25942 (Residues: 21-193; Coverage: 67%)
Gene names: CD40, TNFRSF5
Sequence domains: TNFR/NGFR cysteine-rich region

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21212
Unit cell:
a: 173.308Å b: 75.959Å c: 126.093Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.205 0.265
Expression systems:
  • Cricetulus griseus
  • Homo sapiens