› › Function and Biology

CRYSTAL STRUCTURE OF THE HUMAN PAX-6 PAIRED DOMAIN-DNA COMPLEX REVEALS A GENERAL MODEL FOR PAX PROTEIN-DNA INTERACTIONS

Source organism: Homo sapiens
Biochemical function: DNA binding
Biological process: regulation of DNA-templated transcription
Cellular component: not assigned

Quick links

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00292
Domain description: 'Paired box' domain
Occurring in:
  1. Paired box protein Pax-6
The deposited structure of PDB entry 6pax contains 1 copy of Pfam domain PF00292 ('Paired box' domain) in Paired box protein Pax-6. Showing 1 copy in chain C [auth A].

InterPro InterPro annotations
IPR001523
Domain description: Paired domain
Occurring in:
  1. Paired box protein Pax-6
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. Paired box protein Pax-6
IPR043182
Domain description: Paired DNA-binding domain
Occurring in:
  1. Paired box protein Pax-6
IPR009057
Domain description: Homedomain-like superfamily
Occurring in:
  1. Paired box protein Pax-6
IPR043565
Domain description: PAX family
Occurring in:
  1. Paired box protein Pax-6

Structure domain

CATH CATH domain
1.10.10.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Occurring in:
  1. Paired box protein Pax-6
The deposited structure of PDB entry 6pax contains 2 copies of CATH domain 1.10.10.10 (Arc Repressor Mutant, subunit A) in Paired box protein Pax-6. Showing 2 copies in chain C [auth A].
SCOP SCOP annotation
46748
Class: All alpha proteins
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: Homeodomain-like
Occurring in:
  1. Paired box protein Pax-6
The deposited structure of PDB entry 6pax contains 2 copies of SCOP domain 46748 (Paired domain) in Paired box protein Pax-6. Showing 2 copies in chain C [auth A].

Quick links