X-ray diffraction
1.93Å resolution

Structure of Human NMT2 with myristoyl-lysine peptide and CoA products


Function and Biology Details

Reaction catalysed:
Tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal-N-tetradecanoylglycyl-[protein]
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glycylpeptide N-tetradecanoyltransferase 2 Chain: A
Molecule details ›
Chain: A
Length: 383 amino acids
Theoretical weight: 44.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: O60551 (Residues: 116-498; Coverage: 77%)
Gene name: NMT2
Sequence domains:
ADP-ribosylation factor 6 Chain: C
Molecule details ›
Chain: C
Length: 7 amino acids
Theoretical weight: 836 Da
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P62330 (Residues: 3-9; Coverage: 4%)
Gene name: ARF6

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P21
Unit cell:
a: 63.162Å b: 46.35Å c: 74.395Å
α: 90° β: 114.25° γ: 90°
R R work R free
0.198 0.197 0.218
Expression systems:
  • Escherichia coli
  • Not provided